Which of the following is an example of a metabolic agent?

Which of the following is an example of a metabolic agent?

• A. Chlorine.
• B. Sarin.
• C. Cyanide.
• D. VX.

Answer: (C)

Metabolic agents interfere with the cells’ ability to use oxygen to produce energy. They disrupt cellular respiration so that even with oxygen present in the blood, cells can’t generate ATP, leading to rapid, widespread organ failure. Cyanide does this by binding to cytochrome c oxidase in mitochondria, halting the final step of the electron transport chain. Without ATP, tissues—especially the brain and heart—suffer quickly, making cyanide a classic metabolic agent. Chlorine, by contrast, is a pulmonary irritant that damages the respiratory tract and airways, causing breathing difficulties and tissue irritation rather than shutting down cellular energy production. Nerve agents like sarin and VX disrupt neural signaling by inhibiting acetylcholinesterase, leading to excessive nerve firing and organ overstimulation rather than directly blocking cellular metabolism.

Metabolic agents interfere with the cells’ ability to use oxygen to produce energy. They disrupt cellular respiration so that even with oxygen present in the blood, cells can’t generate ATP, leading to rapid, widespread organ failure. Cyanide does this by binding to cytochrome c oxidase in mitochondria, halting the final step of the electron transport chain. Without ATP, tissues—especially the brain and heart—suffer quickly, making cyanide a classic metabolic agent.

Chlorine, by contrast, is a pulmonary irritant that damages the respiratory tract and airways, causing breathing difficulties and tissue irritation rather than shutting down cellular energy production. Nerve agents like sarin and VX disrupt neural signaling by inhibiting acetylcholinesterase, leading to excessive nerve firing and organ overstimulation rather than directly blocking cellular metabolism.